Monitor serial serum drug levels, and carefully consider the potential benefit of activated charcoal administration or whole bowel irrigation. After overdose, aspirin may be absorbed from the gut into the bloodstream over a prolonged period of time.Principles of medical management of aspirin poisoning Aspirin poisoning is best cared for by clinicians with appropriate knowledge and experience in treating critical drug poisoning. Clinical signs can also develop after days to weeks of therapeutic doses.The following information is also available as a downloadable PDF.Īspirin can be deadly in overdose! Healthcare providers are encouraged to attend to aspirin poisoning cases with the same diligence afforded to cases of sepsis or other life-threatening diseases.Clinical signs can develop within 4-6 hours of ingesting a toxic dose.The half-life of aspirin in cats is between 25-40 hours.Acute toxicity can result in hyperthermia due to the ability of aspirin to uncouple oxidative phosphorylation.This leads to a respiratory alkalosis, followed by a metabolic acidosis Acid base imbalance. Acute massive overdose can directly affect the respiratory center, leading to tachypnea.Salicylic acid irreversibly inhibits thromboxane activity, which inhibits platelet function.Renal blood flow can be affected, resulting in renal damage.Without the protection of prostaglandins and a direct effect of the drug, gastric ulceration can occur.Salicylic acid inhibits the cyclo-oxygenase system, which then inhibits the production of prostaglandins responsible for maintaining tissue homeostasis and modulating blood flow.Aspirin is metabolized by the liver to salicylic acid.
Concurrent use with other non-steroidal anti-inflammatories or glucocorticoids also increases the risk of developing aspirin toxicity.Dehydrated animals are also more likely to develop renal damage.Animals with underlying renal or hepatic disease are more likely to develop toxicity.Clinical signs can develop within 4-6 hours after ingestion of a toxic dose.
Toxic signs can develop at doses over 25 mg/kg/day.In some animals, therapeutic doses can result in GI ulceration. The toxic dose of aspirin in animals varies. Toxicity often occurs due to accidental exposure or inappropriate administration by a well-meaning pet owner.
It is readily absorbed from the stomach and small intestine.
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